Zindaclin (clindamycin phosphate 1%)
To view the Summary of Product Characteristics, please click here.
Adverse events reporting can be found at the bottom of this page.
Zindaclin is an effective topical therapy for mild to moderate acne6. Its once-a-day gel formulation improves patient compliance by combining patients’ preferred attributes. It also contains zinc, which helps to improve skin healing4,5.
Legal category: POM
Cost: £9.95 (30g)
Topical therapies are first-line treatments for mild to moderate acne but they only work if they get used.1
Poor compliance and reduced efficacy are major issues for GPs and dermatologists treating teenagers with acne.2
But ease of therapy and simple dosing regimens have been shown to improve patient compliance.3
A randomised, single-centre cross over study was conducted to determine and compare patient preferences (n=64). Over 4 weeks, patients used each of 3 topical antibiotics for 1 week.2 Patients completed a patient acceptability questionnaire at 1 week of treatment.
Clindamycin phosphate gel received the top overall satisfaction score in the study (p =0.028) compared to other products. Most patients also ranked products that could be applied with the fingers once a day and stored at room temperature over 18 months as their preferred treatment.2
Zindaclin Gel
- Contains the active ingredient Clindamycin Phosphate6
- Simple once a day application
- Zinc improves skin healing4,5
- Reduces inflammation and the appearance of acne7
- Not for use by children under the age of 126
- Read the patient information leaflet carefully before use
References
- https://bnf.nice.org.uk/treatment-summaries/acne/ [Accessed December 2024]
- Kellett, N & West, F & Finlay, Andrew. (2006). Conjoint analysis: A novel, rigorous tool for determining patient preferences for topical antibiotic treatment for acne. A randomised controlled trial. The British journal of dermatology. 154. 524-32. 10.1111/j.1365-2133.2005.07047.x.
- Yentzer BA, Ade RA, Fountain JM, Clark AR, Taylor SL, Fleischer AB Jr, Feldman SR. Simplifying regimens promotes greater adherence and outcomes with topical acne medications: a randomized controlled trial. Cutis. 2010 Aug;86(2):103-8. PMID: 20919606.
- Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020 Nov;33(6):e14252. doi: 10.1111/dth.14252. Epub 2020 Sep 15. PMID: 32860489.
- Lin PH, Sermersheim M, Li H, Lee PHU, Steinberg SM, Ma J. Zinc in Wound Healing Modulation. Nutrients. 2017 Dec 24;10(1):16. doi: 10.3390/nu10010016. PMID: 29295546; PMCID: PMC5793244.
- Zindaclin SmPC [Accessed December 2024]
- Del Rosso JQ, Schmidt NF. A review of the anti-inflammatory properties of clindamycin in the treatment of acne vulgaris. Cutis. 2010 Jan;85(1):15-24. PMID: 20184207.
Adverse events should be reported. Reporting forms and information can be found at: yellowcard.mhra.gov.uk
Adverse events should also be reported to Aspire Pharma Ltd on +44 (0)1730 231148.
